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The cecal apex near the origin of the appendixis thickened due to edema ( arrowheads).

Upper inset.The planeofsection includes only the smooth musclecellsin the vascular wall. Most anti-biotics are given at 2 to 4 half-life intervals—thus attaining therapeutic concentrations onlyintermittently

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Ofthe three, the most important is theZP-3, which functions as the spermatozoa-binding receptorand inducer of the acrosome reaction (see page 845); ZP-2is believed to act as a secondary spermatozoa-binding pro-tein, and ZP-1 has not yet been functionally characterized.In the light microscope, zona pellucida is clearly visible asa homogeneous and refractile layer that stains deeply withacidophilic stains and with the periodic acid-Schiff (PAS)reagents (Plate 92, page 876).

In Box 5.1, two of the sampling frames were rela-tively small (VDPs, and children with cancer at one hospital), and the one forVDPs was also easy to access, so all were approached for participation in thestudy. Patients with moderateand severe persistent asthma are said to have val-ues of 60–80 % and <60 % of predicted, respec-tively.

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